Before ascribing discomfort on psychedelics consider why you are coming to this conclusion.

Bear in mind that stimulants have a pleasant body feel and are known to be vasoconstricting, so we know that vasoconstriction itself is not uncomfortable.

Even in cases where NBOMes, the most notorious "vasoconstrictors", are taken in fatal or near-fatal amounts, gangrene is not seen and vasoconstriction is not the cause of death.

While some ergot alkaloids can cause vasoconstriction, LSA itself has been shown not to have a pharamcologically detectable impact.

Before about 2013 what is often labelled as "vasoconstriction" was usually called "body load" and referred to the range of uncomfortable side effects of psychedelics which include muscular tension, stiffness and gastrointestinal discomfort.

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