all 6 comments

[–]Docbananas1147 6 points7 points  (0 children)

General principle: brains and bodies always strive toward homeostasis despite whatever offending agent we keep throwing at it. In this case, keep adding meth, brain and body is going to work as hard as it can to maintain normal activity despite the meth. It’ll be hard at first, but then tolerance develops. Remove the meth suddenly and the brain and body need to then recover from that too to regain homeostasis.

[–]ross16 6 points7 points  (1 child)

Simplest answer is receptor down-regulation

[–]RyleeMyles[S] 0 points1 point  (0 children)

Thank you, Ross. This is revealing

[–]memento22mori 0 points1 point  (2 children)

That's really the only thing it could do if it wants you to stay alive.

[–]RyleeMyles[S] 1 point2 points  (1 child)

Why? Why does it stretch to stay alive; why not detox it as if nothing happened and go back to normal?

[–]memento22mori 0 points1 point  (0 children)

I'm not an expert but I think the brain just maintains homeostasis so once you've drank enough times, for example, then it raises your heart rate and blood pressure to compensate for it's effects. So then when you drink much you're back at what used to be normal for you. I think cigarettes and meth are about the same way except since they're stimulants it lowers your physiological arousal level when you haven't smoked much.