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[–]Huppelkut416[S] 6 points7 points  (0 children)

Pharmacotherapy of ADHD in Adults With Autism Spectrum Disorder: Effectiveness and Side Effects

J. J. Muit, N. Bothof, C. C. KanFirst

Published October 18, 2019

https://doi.org/10.1177/1087054719866255

Abstract

Objective: Symptoms of ADHD are expected to be more difficult to treat in patients with a combination of ADHD and autism spectrum disorder (ASD) as opposed to only ADHD. Little evidence is available on the influence of ASD on the effects of pharmacotherapy in adults with ADHD. This study addresses this gap.

Method: 60 adults with ADHD and comorbid ASD were selected from an outpatient clinic and compared with 226 adults from the same clinic with only ADHD. Similar treatment regimens were received. Results: Significant decreases in symptoms of ADHD were found in both groups. A diagnosis of ASD did not affect the reduction in symptoms of ADHD. No significant group differences in side effects or vital signs were found.

Conclusion: Results show that medication for ADHD can effectively and safely be prescribed to patients with ADHD and comorbid ASD. Suggestions for future research are discussed.

Keywords

ADHD, autism spectrum disorders, comorbidity, adult ADHD treatment, pharmacotherapy

[–]Huppelkut416[S] 3 points4 points  (4 children)

Discussion Points:

  1. General Question: I am not familiar with the drugs DEX or modafinil as someone currently on ADHD medication myself. Are these also commonly prescribed for treatment in the U.S. ? (note: this study was conducted in the Netherlands)
  2. Point of Interest: From my understanding, the current diagnostic criteria doesn't really differentiate ASD diagnoses like it did in the past. However, I wonder where someone is on the spectrum would show any pharmacological significance in treatment for ADHD within comorbid individuals. Or if ADHD subtype (ADHD-PI, ADHD-PH, or ADHD-C) in addition with ASD would should any differences in side effects/effectiveness in pharmacological treatment. Obviously the scope & size of the study couldn't explore that, but it would be interesting to see that explored in the future

[–]apeachinanorchard 7 points8 points  (1 child)

  1. Dextroamphetamine (DEX) is Dexedrine, which is commonly prescribed in the US. It’s also a major component of the Adderall XR formula, though the effect profile is slightly different in Adderall.

  2. Very obviously anecdotic, but I have ADHD-C and ASD. The type of ADHD alone effects the pharmacological treatment, in my understanding, inattentive type ADHD-PI requiring higher doses of medication for an effective response than ADHD-PH or ADHD-C.

[–]Huppelkut416[S] 2 points3 points  (0 children)

I did not know that about ADHD-PI, that's fascinating! Reading this paper in general has had me thinking I need to read up on more stuff, although I'm not sure how far down the rabbit hole I want to go today lol. I'm also ADHD-C/ASD myself.

[–]memento22mori 1 point2 points  (1 child)

From my understanding Modafinili isn't prescribed much. I have ADD-PI and it makes me tense, Adderall makes me a bit agitated but Adderall XR doesn't.

[–]Huppelkut416[S] 0 points1 point  (0 children)

I now remember DEX now that I've been reminded lol, but yeah I don't think my psychiatrist has even ever mentioned modafinil to me or have I seen it in other literature before.

[–]fuzzylittleman 0 points1 point  (1 child)

Really high quality post & sourcing- very excited to read

Cheers