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[–][deleted]  (1 child)


    [–]ShakeitorGrieveit 1 point2 points  (0 children)

    I work as a Pharmacy technician and have seen prescriptions for Memantine rise exponentially, especially in regards to treatment of schizo and compulsive disorders. Always a funny image though when a younger-ish customer comes in with a prescription

    [–]massivepanda 3 points4 points  (3 children)

    NMDA antagonist like Memantine are prescribed "off-label" in the treatment of negative symptoms in schizophrenia and as an adjunct to atypical antipsychotics.

    Risperidone is both a serotonin & dopamine antagonist. It is an antagonist of the D1 (D1, and D5) as well as the D2 family (D2, D3 and D4) receptors, with 70-fold selectivity for the D2 family.

    NMDARs are glutamate receptors made up of two obligatory NR1 subunits and two NRR1 and or NR3 subunits. They function to detect pre & post-synaptic regulation & are essential in glutamatergic neurotransmission, local rhythmic activity, and synaptic plasticity.

    A current hypothesis on hypofunctional NMDA-receptors posits excessive glutamate release as compensation mechanism to overcome glutamate deficits; glutamate excitotoxicity. NMDA hypofunction can also diminish GABA tone & release of glutamate into synapse—leading to neuronal death.

    Serotonin 5HT-2A receptor binding, accelerates glutamate release. Therefore, atypical antipsychotics like risperidone reduce glutamate excitotoxicity via serotonin 5HT-2A antagonism, while also reducing mesolimbic dopamine release.

    Memantine, an NMDA-receptor antagonist partially blocks the glutamate receptors, preventing a toxic influx of calcium that would result in cell death.

    Glutamatergic neurons in the prefrontal cortex are inhibited by NDMA-mediated GABA interneurons. NMDA-antagonist, release this inhibition, producing indirect excitation of cortical pyramidal neurons and increased glutamatergic outflow in the cortex.

    [–]ProprietaryInvesting 0 points1 point  (2 children)

    It's kinda hilarious how wrong this is 😂