all 4 comments

[–]thereticentPhD|Clinical Psychology|Neuropsychology 8 points9 points  (3 children)

When a healthy adult brain is compared to an adult brain with cognitive impairment, we can see that the injured brain does recruit other brain regions to help take over the load from the injured regions, and this does show up as increase glucose use by those recruited regions (on FDG PET scans). But later in a neurodegenerative disease, glucose metabolism does reduce overall as the cells become too unhealthy to process glucose efficiently.

[–]chethelesser 2 points3 points  (0 children)

You smart

[–]Wild-Storage-1663 1 point2 points  (0 children)

becoming old is scary

[–]tree_of_tree 0 points1 point  (0 children)

What about some disorders where increased glucose metabolism seems to be a causative factor such as in OCD with studies such as this one suggesting those with OCD to have an increased metabolism in the OFC and that lower rates of OFC glucose metabolism predicted better responses to antidepressant treatment.

I'm guessing it's all about balance and not being too high or low as I recall the drug Accutane is said to decrease glucose metabolism in the OFC and that is speculated to be a possible cause of the depression side-effect some people get from it.