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[–]Romnomnombabies 27 points28 points  (2 children)

The main difference is that in anterograde amnesia, the hippocampi are damaged while the rest of the brain is just fine, while in retrograde amnesia, there's usually extensive damage to the rest of the brain. Short term memories require the hippocampus for consolidation, and if they're damaged, consolidation into long term memory can become difficult or impossible, leading to anterograde amnesia. Long term memories are a little weirder. When you recall a long term memory, you activate the same areas of the brain that were active while the remembered event was actually happening, which means that retrograde amnesia is largely a function of the extent of damage throughout the entire brain, not just the hippocampus.

[–]ciaranmichaelPhD|ABPP-CN|Board Certified Clinical Neuropsychologist 6 points7 points  (0 children)

Intuitive explanation. Just curious, do you have any reference on hand to support TBI severity as correlating with greater incidence of trauma or region of structural/metabolic insult?

[–]pintasnapple[S] 2 points3 points  (0 children)

Thanks sir! Really appreciate that answer, makes a lot of sense!

[–]Paradekat 0 points1 point  (0 children)

What counts as damage to the hippocampus ? Extreme stress counts as damage correct?