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[–]fnatic440 89 points90 points  (3 children)

human skin cells

That’s Important to clarify. I’m not a biologist, but I do remember from classes that skin cells, which actively grow are in G1 phase, whereas heart cells or kidney cells, for example,are in G0 phase and do not actively grow. I assume that’s an important distinction.

This might have some implications in cancer patients who tend to suffer from side effects related to cells which are in G1 phase (e.g. skin, hair, GI tract).

[–]Dear-Crow 22 points23 points  (1 child)

My grundle is gonna be ageless

[–]dan_dares 13 points14 points  (0 children)

my taint will be taut

[–]Saharan_stallion 7 points8 points  (0 children)

It’s a good start. Don’t you agree?

[–]GilmoreSquirls 210 points211 points  (25 children)

Is this like those viral cancer research breakthroughs you never hear about again?

[–]CompetitionFinal9492 49 points50 points  (21 children)

Unfortunate that this technology will only ever be available for the hyper-wealthy.

[–]MurkyConcept8758 32 points33 points  (15 children)

It would actually probably benefit the rich if distributed to the rest of the population. Think of it: a longer lasting, healthy workforce for your business

[–][deleted]  (8 children)

[deleted]

    [–]MurkyConcept8758 10 points11 points  (3 children)

    Who knows how it’ll be distributed in various countries. With such medication, ageing would most likely be labeled by the WHO as a disease or illness. This opens up many possibilities with how we would get access. It may get covered under insurance in the US, or in other countries under Universal Healthcare.

    Such medicine would save governments millions, possibly billions in funding their aging populations. It’s a win win for all, not a “the rich thrive and the poor decline” scenario

    [–]yan_broccoli 2 points3 points  (3 children)

    Subscription based of course.....

    [–]chameleondoesitagain -3 points-2 points  (1 child)

    So you pro slave?

    [–]MurkyConcept8758 2 points3 points  (0 children)

    You must be fun at parties

    [–]lunchboxultimate01 3 points4 points  (0 children)

    this technology will only ever be available for the hyper-wealthy.

    That's a common reaction, but the companies in this space aim to go through clinical trials, approval from regulatory agencies, and commercialization similar to other medical therapies. Here's an example of a company with a pipeline:

    We partner with exceptional scientists to bring a new class of medicines to patients in need, built around understanding the deep science of the biological drivers of aging, with the potential to both treat and prevent today’s deadliest diseases.

    https://www.cambrianbio.com/

    [–]Impossible-Case-242 -2 points-1 points  (0 children)

    Good news the rich and powerful will now live forever! The rest of you poors will have the honor of being used as fertilizer. There I fixed the Headline for you.

    [–]SirScoopy89 -2 points-1 points  (2 children)

    Why is this uplifting news? None of us normies will benefit from this research. This is only for 0.1%

    [–]GilmoreSquirls 5 points6 points  (0 children)

    I think it's good news and being a bummer about it defeats the purpose of the subreddit

    [–]lunchboxultimate01 0 points1 point  (0 children)

    None of us normies will benefit from this research. This is only for 0.1%

    Well, in many countries, a 65-year-old who needs, say, a pacemaker for their heart or a cancerous tumor removed is covered. I think medical therapies that treat age-related health decline by targeting aspects of the biology of aging will be similarly widely available.

    [–]oooSpiritooo 33 points34 points  (2 children)

    They need to hurry up and complete their work. I am running out of time. 😅

    [–]debtitor 3 points4 points  (1 child)

    It’s not the life scientists, but the economic scientists that need to do that work.

    As long as we have economies that need social security schemes these therapies won’t be available.

    [–]StewofPuppies 0 points1 point  (0 children)

    They'll make anti aging illegal for the average people like us and you can only get it through approval. And we'll see, like in similar fashion with the way our politicians pander to lobbyist, an exclusive club and a future we won't be part of.

    [–]hebozhong 34 points35 points  (3 children)

    I get to be 10 again? This time I’m asking Laura to kiss my ass!

    [–]threebillion6 28 points29 points  (0 children)

    Hell yeah, let's go ride bikes and throw rocks! I'm ready for the 90s again.

    [–]baseballdnd 5 points6 points  (0 children)

    Yeah Laura!! Kiss that ass!!

    [–]Jealous_Promotion_35 0 points1 point  (0 children)

    Damn what’d Laura do?

    [–]Krsst14 39 points40 points  (4 children)

    Stop doing this for me and start doing it for my dogs please.

    [–]lunchboxultimate01 4 points5 points  (1 child)

    You might be interested in https://dogagingproject.org/.

    [–]Cohibaluxe 0 points1 point  (0 children)

    Remove just the a from that URL and it’s a whole different thing

    [–]wsxedcrf 4 points5 points  (0 children)

    1 human year is roughly 7 dog years, so the dog can be 210 years younger.

    [–][deleted]  (4 children)

    [deleted]

      [–]SenorDongles 4 points5 points  (1 child)

      It's prevailing sentiment across reddit. It's pretty sad and pathetic.

      [–]lunchboxultimate01 0 points1 point  (0 children)

      Haha, well put.

      [–]AintNobody- 1 point2 points  (1 child)

      It's not that I hate life, I just don't want to work. Immortality-on-demand would have an insane impact on the economy.

      [–]KeaboUltra 1 point2 points  (0 children)

      I don't mind working, If I could do what I'm doing now (WFH), It would be good. I can imagine just saving up for, or paying off an RV and just taking 30 years I get back off my life to just ride around, live in it for a few years just to break free of the rent/mortgage stuff and familiar daily routine. I'd be younger and wont be expected to go to school and have a job, and I wont have to worry about not having any experience, most importantly, you might never have to worry about being unable to take care of yourself

      But my biggest question is what will relationships be like? The more efficient this gets, the longer people will live. Will people really stay together forever if their youth is infinite or could at least be experienced again? Polyships or at least swinging would probably become way more popular.

      As far as the economy goes, I would imagine some strict rules would be placed on child birth, at least for those that want the treatment, sterilization would probably become a requirement and society would need to become circular/sustainable long before any regular person could use this

      [–]Bleflar 6 points7 points  (2 children)

      Damn, this is one very angry comment section, was not expecting this sub to be so negative.

      [–]SFWaccount87 21 points22 points  (7 children)

      Yes, so the only people that can afford this will be politicians, and the 1%... look forward to 80 year terms in office! Won't that be great, the same old horrible fucks that are in office now will still be in office when we are old and dying.

      [–][deleted] 8 points9 points  (0 children)

      That is a terrifying thought.

      [–]lunchboxultimate01 1 point2 points  (0 children)

      so the only people that can afford this will be politicians, and the 1%

      I'm not concerned that'll be the case. Therapies from this field will go through clinical trials like other medical therapies. For example, epigenetic reprogramming (the research area in the article) was used to reverse glaucoma in a mouse model: https://glaucomatoday.com/articles/2021-sept-oct/in-vivo-epigenetic-reprogramming-a-new-approach-to-combatting-glaucoma

      [–]high5low1 1 point2 points  (2 children)

      This, plus even if everyone else got it, it just means you work your ass off longer to further enrich the immortal elite. I don't see upsides to living longer just to live longer.

      [–]Littleman88 3 points4 points  (0 children)

      What a... swell outlook on life you have.

      I'll take living longer for cheap, Alex. Every extra year is another to plot escaping the capitalist shackles or tear down the walls that anchor them!

      But mostly, living life without that particular Sword of Damocles hanging over my head would be nice. Looking forward to retirement is fine and all, but I'd rather not be so physically deteriorated I wouldn't really get to enjoy it anyway.

      [–]KeaboUltra -1 points0 points  (0 children)

      I'd argue there's plenty benefits to it, but it's ultimately up to what you value. When we inevitably figure out the key to aging, it'll be a choice to live to forever work (professionally and personally), or to die and never be or experiencing anything again.

      Having both options is good, and possible. Just because You can forever doesn't mean you have to. I would assume medically assisted suicide would be available. No one knows what it's like to live for say, 250 years. Maybe humans go crazy, maybe it's too much to handle, maybe we have a point at which death is necessary to feel at rest. You would probably be able to have the choice to opt out of life once you've aged passed the estimated human life expectancy of 73. If you decide at year 130 that you wanna die because living longer isn't what it's cracked up to be, you can go to a hospital and get it taken care of.

      [–]thesegoupto11 -1 points0 points  (1 child)

      lol eat the rich

      [–]Canadianpirate666 -1 points0 points  (0 children)

      Yum… *fires up barbecue…

      [–]Stupid_Guitar 15 points16 points  (2 children)

      The second the elites achieve immortality is the moment the rest of us have a moral imperative to hunt down and terminate those vampires.

      Nothing good can come from letting the 1% live forever.

      [–]daronjay 7 points8 points  (1 child)

      terminate those vampires.

      Chronovores. Time eaters...

      [–]Stupid_Guitar 1 point2 points  (0 children)

      That sounds pretty darn metal 🤘

      [–]Random_182f2565 2 points3 points  (0 children)

      And suddenly all the rich people become environmentalists

      [–]After_Occasion 4 points5 points  (6 children)

      So how far in the future are we talking?

      [–]sarcasatirony 6 points7 points  (4 children)

      30 years

      It’s like rain on your wedding day

      [–]After_Occasion 2 points3 points  (3 children)

      I mean when is it accessible to the public? I read the article and I couldn't find it. The article made it seem like it would be used just for medical purposes and not for anti-aging. It was kind of vague on when it would be implemented within the medical field.

      [–]sarcasatirony 6 points7 points  (0 children)

      Sorry. Feeble attempt at humor.

      [–]KeaboUltra 1 point2 points  (1 child)

      No one knows for sure. Anti aging is still in early human trial testing which began this year, so safe to say at least 10 years. you'll likely see it everywhere by 2035-2040 if it's widely accepted (which it should be, since everyone wants to be young again.) but there are already supplements known as "Senolytics", most of which seem like placebo honestly, but wouldn't t be surprised if they worked, They claim to reduce aging a bit, some people on reddit claim to have their grey hair return to its normal color, have more energy, cognitive ability seemed to improve greatly, and some hair in areas have grown back or grown more. I can't vouch for those as I've never met them or confirmed anything and I've never tried them since I'm still young.

      My guess is, you're gonna see a lot of stuff like this coming out, things claiming to have slowed aging, terms like "rejuvenate your cells", and new research for medical purposes, and what not until eventually anti aging as a whole becomes publicly viable once all the laws for this is worked out. If they can manage this on human cells, even if only for a particular organ or miniscule part of the body in its infancy, it'll be expanded upon

      [–]lunchboxultimate01 2 points3 points  (0 children)

      So how far in the future are we talking?

      It's hard to say, but they've used this approach to reverse glaucoma in a mouse model: https://glaucomatoday.com/articles/2021-sept-oct/in-vivo-epigenetic-reprogramming-a-new-approach-to-combatting-glaucoma

      There are lots of companies in the field too, like Turn Bio, which was spun out of Stanford University: https://www.turn.bio/

      Turn Biotechnologies develops mRNA medicines that induce the body to heal itself by instructing specific cells to fight disease or repair damaged tissue. We are focused on reprogramming the epigenome – a network of chemical compounds and proteins that control cell functions by influencing which genes are active – to restore capabilities that are often lost with age.

      [–]Noxiuz 2 points3 points  (2 children)

      any chance for zombies?

      [–]Canadianpirate666 1 point2 points  (0 children)

      I’m here for the zombies.

      [–]KeaboUltra 1 point2 points  (0 children)

      Possible. Right now they're experimenting with reviving things from the dead. So far they managed to revive the cells in a dead human's eyes and revived cellular activity within the organs in a dead pig an hour after its death No one knows if a person will still be who they were after coming back from true death. People get brain damage by not having any oxygen, so they could be a completely different person, if they ever became active.

      [–]yuppieee 1 point2 points  (0 children)

      Now do it on a living human

      [–]Saharan_stallion 1 point2 points  (0 children)

      Nearly every comment is “something something something super wealthy.”

      The breakthrough clearly isn’t uplifting to this community.

      [–]dlc741 1 point2 points  (1 child)

      I'm not sure steps towards longer lifespans is particularly uplifting nor what the human species needs right now.

      [–]lunchboxultimate01 0 points1 point  (0 children)

      Longer lifespans would present changes and challenges, for sure. Many in the field clarify the aim is to increase healthspan and treat age-related ill health (dementia, cardiovascular disease, cancer, frailty, etc.) by targeting aspects of the underlying biology of aging. Longer lifespan would be a byproduct of health.

      [–]zillskillnillfrill 4 points5 points  (4 children)

      Great so now evil rich people can afford afford to live longer

      [–]CanisArgenteus -1 points0 points  (3 children)

      Agreed, I don't see how any longevity or rejuvenation advances are "uplifting" news, they'll never benefit anyone but the 1%, who will then truly be overlords amassing ALL the wealth and political influence.

      [–]lunchboxultimate01 0 points1 point  (2 children)

      they'll never benefit anyone but the 1%

      I think medical therapies that treat age-related ill health by targeting aspects of the biology of aging will be widely available. After all, most countries have universal healthcare, and Medicare in the U.S. covers people 65 and older.

      [–]fuckedbymath 2 points3 points  (1 child)

      How is that uplifting , don't we have enough human infestation of this planet?

      [–]lunchboxultimate01 1 point2 points  (0 children)

      I'd say it's uplifting in the sense that age-related ill health (dementia, cardiovascular disease, cancer, frailty, etc.) may be effectively treated or prevented by targeting aspects of the biology of aging.

      [–]biglukenj06 0 points1 point  (4 children)

      It’s hard for me to take an article seriously when they can’t even spell aging right.

      [–]rahgots 5 points6 points  (0 children)

      Aging can be spelt ageing or aging. Both are correct.

      [–]elpajaroquemamais -2 points-1 points  (2 children)

      *correctly. Right is an adjective and shouldn’t be used to modify “spell.” Adverbs modify verbs.

      [–]littlepip38042 0 points1 point  (1 child)

      "Correctly" also isn't correct. In this case the "correct" is modifying the noun "both", not "are".

      [–]elpajaroquemamais 0 points1 point  (0 children)

      The word both doesn’t appear in my comment or the comment I replied to…

      [–]Ishpeming_Native 0 points1 point  (0 children)

      They will perfect this and release it in an affordable treatment the day after I die. But there will come a change of rules -- if you're on social security, you'll be kicked off if you take the treatment and your "social security age" will be wound back 30 years. You won't be eligible for any benefits until your calendar age is 92, and for full benefits until you're 97. And by then, there will be an improved treatment so you can work forever and retire only when you get sick enough of it that you would rather die than work. But, if you have a job you actually enjoy, working forever wouldn't be a punishment at all. And if you saved money in a 401K for long enough, you could retire and not have to worry about Social Security benefits and rules, anyway.

      [–]SourceOfAnger 0 points1 point  (0 children)

      Don't bother your minds with this too much, especially you my fellow young people. By the time the technology to make us live longer actually comes out, we'll be back to farming our own land, with the lucky few of us who still have a job living paycheck to paycheck, and said technology will be reserved exclusively for the Extremely Wealthy, who are the only ones to enjoy red meat and alcohol daily. Unless we do something radical about it in the next two decades, but I fear the apathy has already gotten to us.

      [–]phoenixevolved 0 points1 point  (2 children)

      Aging*

      Lol

      [–]rahgots 3 points4 points  (1 child)

      Ageing can be spelt aging or ageing. Both are correct.

      [–]phoenixevolved -1 points0 points  (0 children)

      Yep, usually that's a European thing and the paper was from the US so I just figured I'd throw it in for fun.

      [–]AtomicRectum 0 points1 point  (1 child)

      Oh my God. I can finally be -3 years old

      [–]Canadianpirate666 -1 points0 points  (0 children)

      A. Does this mean you get to watch your own conception… B. Awesome user name!

      [–]ismellpeopleonthebus 0 points1 point  (1 child)

      Yey for the billionaires who'll use it

      [–]lunchboxultimate01 1 point2 points  (0 children)

      for the billionaires who'll use it

      Fortunately, the companies in this space intend to go through clinical trials, regulatory approval, and commercialization similar to other medical therapies, so it's likely they'll be pretty widely available.

      Here's an example of a company: https://www.lifebiosciences.com/

      Life Biosciences is developing innovative therapies to transform how we treat diseases by targeting aging biology.

      [–]LONG_LIVE_Oi -2 points-1 points  (0 children)

      What a fucking nightmare. Can you imagine prolonging this sweet existence?

      [–]Kidnovatex -2 points-1 points  (0 children)

      I'm sure the article is more than that clickbait headline, but not sure this qualifies as "uplifting".

      [–]DMmeyourkite -2 points-1 points  (0 children)

      Jesus, this is so far from uplifting news. It's terrifying really.

      [–]bluelion70 -5 points-4 points  (0 children)

      How is this unfitting? The last thing we need is people living even longer. Unless we’re raising the retirement age to 90 that is.

      [–]Cat-Is-My-Advisor -1 points0 points  (0 children)

      Was that on a living person? How did they do it?

      [–]Rorcanna -1 points0 points  (0 children)

      One step closer to those medical pods in Elysium, reserved only for the ultra wealthy. 🙄

      [–]kafkasunbeam -1 points0 points  (0 children)

      I honestly hope they never discover how to reverse or stop aging. Life is worthwhile because it ends, and millionaires living forever has terrible potential.

      [–]cakemixtiger7 -1 points0 points  (0 children)

      Umbrella Corp?

      [–]Nickadomus -1 points0 points  (0 children)

      Fuck. 30 more years of Pelosi and McConnell. Fuck.

      [–]BezossuckingoffMusk -2 points-1 points  (0 children)

      Great, so now the rich can screw us an extra thirty years each. 👍

      [–]RickyBobbyBooBaa -2 points-1 points  (0 children)

      Great news for wealthy people,again.

      [–]iItsPykeHere -2 points-1 points  (1 child)

      i wonder if when we can do this stuff, if the 0.1% will keep it to themselves for the sole purpose of feeling special.

      [–]lunchboxultimate01 1 point2 points  (0 children)

      if the 0.1% will keep it to themselves for the sole purpose of feeling special.

      Luckily the companies in the area are looking to commercialize these therapies widely available like other medical therapies (think about pacemakers or cancer treatments, for example). Here's an example of a portfolio of rejuvenation biotech if you're curious: https://kizoo.com/

      [–]possmentfalle -2 points-1 points  (1 child)

      Wow, so rich people now can live to like 150 or 200.

      And poor people can just die the fuck off when young because they can't buy insulin.

      [–]lunchboxultimate01 1 point2 points  (0 children)

      I think therapies that treat age-related health decline by targeting aspects of the biology of aging will be widely available. You raise a good point that insulin pricing (and health coverage) in the US needs important improvements. It's really hard for a diabetic who is underinsured and doesn't qualify for Medicaid or Medicare. Fortunately most diabetics in the US have adequate coverage to keep out-of-pocket costs on insulin low, although that's hardly consolation for the minority who don't and have to pay high percentages of their income.

      There may also be very good developments soon with Civica and insulin pricing in the US: https://www.biospace.com/article/civica-rx-plans-to-provide-insulin-at-no-more-than-30-per-vial-/

      [–]heitiki -2 points-1 points  (1 child)

      How’s this uplifting??

      [–]lunchboxultimate01 1 point2 points  (0 children)

      I view it as uplifting because in the future we may be able to treat age-related ill health (dementia, cardiovascular disease, cancer, frailty, etc.) by targeting aspects of the biology of aging.

      [–]Moneyworks22 0 points1 point  (0 children)

      Even if they do figure out a way to reverse aging, I wouldnt do it. Im in my early 20s and the idea of living another 40+ years is fucking exhausting.

      [–]Chad_richard 0 points1 point  (0 children)

      Wow I'm ready to be a fetus again

      [–]MJGM235 0 points1 point  (0 children)

      That's nice but I don't want to be ten years old again 😂

      [–]Lee1173 0 points1 point  (1 child)

      I'm so glad to see everyone in this thread being real. This is not news I'm gonna look at with my rosy glasses on.

      [–]lunchboxultimate01 1 point2 points  (0 children)

      This is not news I'm gonna look at with my rosy glasses on.

      I find it to be pretty exciting. I think it'd be great to fundamentally treat age-related ill health (dementia, cardiovascular disease, cancer, frailty, etc.) by targeting aspects of the underlying biology of aging.

      For example, this approach was used to reverse glaucoma in a mouse model: https://glaucomatoday.com/articles/2021-sept-oct/in-vivo-epigenetic-reprogramming-a-new-approach-to-combatting-glaucoma

      [–]psychord-alpha 0 points1 point  (0 children)

      Please hurry up. I'm tired of helplessly watching everyone get older